端粒酶逆转录酶(TERT)重组蛋白

端粒酶逆转录酶(TERT)重组蛋白介绍：

【Alternative Names】EST2; TCS1; TP2; TRT; hEST2; Telomerase catalytic subunit; Telomerase-associated protein 2

【Host】E.coli

【Traits】 Freeze-dried powder

【Concentration】200μg/mL

【Buffer formulation】PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

【Predicted Molecular Mass】63.4kDa

【Accurate Molecular Mass】65kDa as determined by SDS-PAGE reducing conditions

【Note】For research use only. Not intended for diagnostic or therapeutic use.

【Storage】Store at 2-8ºC for one month.Aliquot and store at -80ºC for 12 months.Avoid repeated freeze/thaw cycles.

【instructions】Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, and that Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].

多肽和蛋白质主要区别是它们的结构不同、功能不同、内涵不同，具体区别如下所示：

1、结构区别

多肽不具备空间结构，而蛋白质具有一定的空间结构。多肽指的是由多个a-氨基酸以肽键连接在一起而形成的化合物，是蛋白质水解的中间产物，由两个氨基酸脱水缩合形成的化合物叫二肽，以此类推有三肽、四肽、五肽等。通常情况下，10~100个氨基酸分子脱水缩合形成的化合物叫多肽，不具备空间结构；蛋白质是指有a-氨基酸按一定顺序排列的一条多肽链，再由一条或多条的多肽链按其特定方式进行结合，形成的高分子物质，具有一定空间结构。

2、功能区别

多肽一部分具有生物学活性，一部分不具有生物学活性；蛋白质都具有生物学活性。

3、内涵不同

多肽一般是强调线性序列，即一级结构；蛋白质一般是强调一个三维空间结构的术语，即蛋白质具有二级结构、三级结构和四级结构。

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